Modeling of regulatory mechanisms of oncogenic viruses Micro-RNA action

Life cycle of RNA oncogenic viruses.

In view of the increasing evidence suggesting that human Cancer cells contain molecular footprints related to murine and primate type-C RNA tumor viruses (1-7), it is appropriate in this symposium to discuss a simple scheme for the life cycle of RNA tumor viruses. It is hoped that this scheme will be useful in searching for virus related proteins, nucleic acids and particulates in human leukemi...

RNA viruses – evolution in action

remain unreconciled with frequent anthropomorphic interpretations of their own work. To others, the theory of evolution is additionally difficult to comprehend and win universal acceptance because it operates so slowly and imponderably on the most important objects of study, ourselves and the primates from whom we descend. With RNA viruses, however, we have the opportunity to observe evolution ...

Mechanisms of genetic robustness in RNA viruses.

Two key features of RNA viruses are their compacted genomes and their high mutation rate. Accordingly, deleterious mutations are common and have an enormous impact on viral fitness. In their multicellular hosts, robustness can be achieved by genomic redundancy, including gene duplication, diploidy, alternative metabolic pathways and biochemical buffering mechanisms. However, here we review evid...

Oncogenic Viruses

Oncogenic Dna and Rna Viruses Causing the Cancer Pathogenesis

The present paper explore out the better-characterized and most intensively studied oncogenic viruses of humans and animals. Many DNA and RNA viruses have been proved to be oncogenic (or carcinogenic) in a variety of animals, ranging from amphibia to primates, and évidence grows stronger that certain forms of human cancer are of viral origin. Several DNA viruses have been associated with the ca...